Future of Rail: trends in rail passengers, rail freight, railway innovation - Rail Trends Keynote

Future of the Auto Industry - mega trends impacting the auto industry. Futurist Keynote for Belron

How to make virtual keynotes more real and engaging - how I appeared as an "avatar" on stage when I broke my ankle and could not fly to give opening keynote on innovation in aviation for. ZAL event in Hamburg

"I'm doing a new book" - 60 seconds to make you smile. Most people care about making a difference, achieving great things, in a great team but are not interested in growth targets. Over 270,000 views of full leadership keynote for over 4000 executives

Futurist Keynote Speakers - how Futurist Keynotes transform events, change thinking, enlarge vision, sharpen strategic thinking, identify opportunities and risks. Patrick Dixon is one of the world's best known Futurist Keynote Speaker

Futurist Keynote Speaker: Colonies on Mars, space travel and how digital will help us live decades longer - comment before keynote for 1400 at Avnet Silica event

Future of Travel and Tourism after COVID. Boom for live experiences. What this means for future of aviation, airlines, hotels, restaurants, concerts halls, trends in leisure events, theme parks. Travel Industry Keynote Speaker

Quiet Quitters: 50% US workforce wish they were working elsewhere. How engage Quiet Quitters and transform to highly engaged team members. How to tackle the Great Resignation. Human Resources Keynote Speaker

The Great Resignation. 50% of US workers are Quiet Quitters. They have left in their hearts, don't believe any longer in your strategy. 40% want to leave in 12 months. Connect with PURPOSE to win Quiet Quitters. Human Resources Keynote Speaker

Future of Human Resources, virtual working, hybrid teams, motivation, management, future of motivation and career development. How to develop high performance teams. HR Keynote Speaker

Speed of change often slower than people expect! I have successfully forecast major trends for global companies for over 25 years. Focus on factors driving long term changes, with agile strategies for inevitable disruptive events. Futurist Keynote Speaker

Agile leadership for Better Risk Management. Inflation spike in 2022-3 - what next? Expect more disruptive events, while megatrends will continue relentlessly to shape longer term future globally in relatively predictable ways. Futurist Keynote Speaker

Crazy customers! Changing customer expectations. Why many decisions are irrational. Amusing stories. Lessons for Leadership, Management and Marketing - Futurist Keynote Speaker VIDEO

TRUST is the most important thing you sell - TRUE for every business. How to BUILD TRUST, win market share, retain contracts, gain new customers. Future of logistics and supply chain management - Futurist Keynote Speaker

Future of Sales and Marketing beyond COVID - hybrid event in Vilnius: physical audience of 800 + 300 virtual. Digital marketing, location marketing. How to create MAGIC in new marketing campaigns. Future of Marketing Keynote Speaker

Chances of 2 people in 70 having same birthday? Managing Risk in Banking and Financial Services. Why the greatest risks are combinations of very unlikely events, which happen far more often than you expect. Keynote speaker on risk management

Compliance is Dead. How to build trust. Reputation of banks and financial services. Compliance Risks. Why 100% compliance with regulations, ESG requirements etc is often not enough to prevent reputational damage

Life's too short to do things you don't believe in! Why passionate belief in the true value of what you are selling or doing is the number one key to success. Secret of all leadership and marketing - keynote for 1100 people in Vilnius October 2021

Future Manufacturing 5.0. Lessons from personal life for all manufacturers - why most manufacturing lags 10-15 years behind client expectations in their day to day life. Manufacturing 4.0 --> Manufacturing 5.0. Future of Manufacturing Keynote

80% of sales are won or lost in 3 seconds, How to grow your business by giving attention to small things that really matter. Future of Marketing, Futuris Keynote Speaker - Pardavimu formule in Vilnius

New therapies for COVID and impact on future healthcare. Why effective, low-cost antiviral treatments will be more important than COVID vaccines in longer term. Truth about global fight against new viruses each year. Future of healthcare keynote speaker

Futurist Keynote Speaker: Posts, Slides, Videos - Future Health Care and Pharma Keynote Speaker

What will be the longer term impact of COVID on the future of health care? People often say to me that the answer to new viral pandemics is to develop vaccines.  This is clearly nonsense since it takes months to develop a vaccine, months more to test, years to vaccinate the world at vast cost, and the vaccine itself may not produce long term immunity, or may be overtaken by new mutations.

That is why for two decades now I have been warning of the need to develop next-generation antivirals.

We still don't have a single antiviral today that is as powerful and effective as penicillin was against bacteria when first discovered over 80 years ago.

But one benefit of vaccines is buying us time to learn about new viruses so we can reduce death rates with better therapy.

What we have learned about treating COVID-19

Research falls mainly into three areas: antivirals, immune modulators and drugs to prevent blood clotting.  Here are some examples - this area of medical research is growing at astonishing speed.

Thousands of clinical trials are under way, many reporting some early findings that are promising but yet to be proven in impact or safety.

Aspirin

Low dose (75mg) seems to reduces the risk by over 40% of someone with COVID-19 being admitted to hospital or going on a ventilator. Aspirin helps prevent widespread clotting of small blood vessels which is a common complication. Published research in Anaesthesia and Analgesia 17 March 2021.

Dexamethasone

It's been estimated that by March 2021, over a million lives had been saved in intensive care units of people very sick with COVID-19. Dexamethasone dampens down the immune response which can go into overdrive in the second week or beyond, after the first phase of infection ends.  NHS UK announcement 23 March 2021.

Tocilizumab

Saves an extra 1 in 25 people who are given dexamethasone for severe COVID-19 illness. RECOVERY trial in UK - preliminary results announced 11 February 2021.

Budesonide 

Pulmicort, manufactured by AstraZeneca for asthma patients - appears to reduce risk of ending up in hospital by 90% if you become infected by COVID-19. Oxford University research - preliminary results announced 9 February 2021

EXO-C24

Experimental Phase 1 clinical trial drug - Israel research - suggests that 95% of patients are cured of COVID-19 inn a few days.  Exosomes are packed with CD24 particles which are inhaled straight into the lungs where they damp down cytokine storms (immune over-reaction).  Preliminary annoucement 8 February 2021.


Drugs being investigated include:


Antivirals

Remdesivir

Chloroquine/hydroxychloroquine

Lopinavir/ritonavir combination

Favipiravir

Umifenovir

Ribavirin

EIDD-2801

Niclosamide

Oseltamivir

Ivermectin


Immune modulators

Dexamethasone

Hydrocortisone

Convalescent plasma

Budesonide (inhaled)

AZD7442

Azithromycin

Doxycycline

Interferons

Tocilizumab

Sarilumab

Canakinumab

Anakinra

Baricitinib

Ruxolitinib

Acalabrutinib

Brensocatib

Ravulizumab

Gemtuzumab ozogamicin

Namilumab

Infliximab

Adalimumab

Otilimab

Medi3506


Antiviral antibody cocktail

Leronlimab

LY-CoV555

LY-CoV016

Risankizumab

Lenzilumab

IMU-838


Other or multiple mechanisms

Colchicine

Dimethyl fumarate

Angiotensin-converting-enzyme inhibitors/angiotensin II receptor blockers

Statins

Aspirin

Clopidogrel

Anticoagulants

Bemcentinib

Omeprazole

Famotidine

Zilucoplan

Ascorbic acid/vitamin C

Vitamin D3

Aviptadil

Opaganib

Tradipitant

AZD1656

Nitric oxide

Razuprotafib

Fluvoxamine

Proxalutamide



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