Cloning of Mouse - Frozen for 16 years

Futurist Topics - Cloning

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Scientists in Kobe, Japan, have successfully cloned mice from another mouse which had been frozen for 20 years. They removed the nucleus from brain cells which had been thawed out, and fused each nucleus with an unfertilised egg from which the nucleus had been removed. They gave each egg a small electric shock to simulate penetration by a sperm, and some began dividing normally into clones of the original mouse. They then implanted these cloned embryo into mouse wombs, where some developed normally. (1st November 2008)

What is remarkable about this animal cloning announcement is that these cells were taken from whole mice, which had not been treated in any special way before freezing. When living or dead tissue is frozen, small ice particles usually grow inside cells which often result in great damage to cell structure. For this reason, scientists usually remove cells from the body of an animal or human that they want to preserve by freezing, and soak the cells in a kind of antifreeze to prevent cell damage.

There is nothing new in cloning animals from frozen cells. Dolly the Sheep was the first animal cloned in this kind of way in 1997, and Australian researchers cloned a pig in 2001 from cells that had been frozen for two years.

So could extinct animals be cloned from frozen bodies preserved in permafrost? While this is a small possibility, the reality is that even at -20 degrees centrigrade, decomposition still happens slowly, and permafrost is often warmer than that. Bodies need to be as cold as - 140 degrees centigrade or more to totally stop cells becoming more damaged as time goes by.

Human cloning - grieving relatives who want to clone the dead

For some time people have contacted me on this website asking about ways to recover their loved ones using human cloning techniques - maybe from frozen tissue taken before death and held for research purposes in laboratories. There is no doubt that today's news will increase the number of people who think about such things. There is a fascination about human cloning research despite the huge risks, and some scientists have made claims in the past that they have implanted viable human cloned embryos into mothers to produce healthy babies. (Claims have never been proven, but a growing number of research centres are cloning human embryos routinely for medical research - so-called therapeutic human cloning. These embryos are used as sources of cell lines for growing in culture and the embryos themselves are destroyed at 14 days after fertilisation.)

However we need to look at the facts: cloning of animals requires a huge number of attempts to get successful births. Many cloned animals either die in the womb from malformations or are born with major life-threatening abnormalities. Even if scientists could manage to produce a healthy human clone from someone who died many years ago and who had been frozen, or had tissue samples frozen, it is hard to imagine the huge psychological risks to the wellbeing of such a child as they grow up.

That may not stop a very small minority of wealthy people in future, who may be driven by a desire to see dead people cloned - relatives, heros of history, people whose genes they admire.

I remember in 1998 a woman called Diane e-mailed me after her father died. She wrote that her father was a remarkeable man, "and I intend to see that he goes on in the world". Diane's hope was to be able to clone her father using a donated egg and some of her father's cells. She wanted to have the clone of her father implanted into her own womb, so she would give birth to a child that would technically be her uncle.

Please do COMMENT on the news story using the form below.

* The Japanese research into cloning a frozen mouse was undertaken at Kobe's Centre for Developmental Biology, reported in journal Proceedings of the National Academy of Sciences (PNAS).

Many more articles and videos on human cloning


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There are 19 comments
naijil george
July 06, 2009 - 23:13
Subject: retun of peoples who passed away.

Your aim was nice but if we clone from once cell it may not be intelectually simillar to the orginal one. genitic variation and the environ mental thing will affect the behavior and all. So we cant except the same from the cloned one.

Jimmy
July 02, 2009 - 10:50
Subject: The loved one cloned

The laws should be made to allow cloning be done to the loved ones,that is in case they die.

mahaveer
May 14, 2009 - 05:10
Subject: Cloning

it is better if you keep a video showing how cloning is done with the help of animation. tell me is human cloning is good or not. i think it is good if done with good thought.

Daniel
May 02, 2009 - 03:09
Subject: we should clone the biggest scientists ever

like einstein and da vinci
to finish some of his work

Reply to Daniel
naijil george
July 06, 2009 - 23:08
Subject: Re: we should clone the biggest scientists ever

Your aim was nice but if we clone from once cell it may not be intelectually simillar to the orginal one. genitic variation and the environ mental thing will affect the behavior and all.

sniffcode.com
March 11, 2009 - 23:02
Subject: What's the Point of Cloning Animals?

I guess I can appreciate this from a research perspective. But in the end I don't see the point of cloning an animal. For one, personality and behavior will differ between genotypic twins. Any personality similarities will be attributed to temperament common to a particular breed only. In that case, just go buy another animal of the same breed. Chances are it will look nearly identical to the last one.

David
March 01, 2009 - 13:14
Subject: cloning

well they might not know you cuz if you clone my grandma im going to be older than she is if im 23 then my grandma was cloned that would be strange

i got ur mum
February 25, 2009 - 03:41
Subject: cloning

i bet i could clone a mouse, it's not exactly hard i mean they're simple, hillbillies do it everyday.

jo
February 08, 2009 - 14:12
Subject: human cloning

It sounds good but i'm against human cloning, were not god, your creating someone else; a look a like not the real person they wont have the same memories. todays society have a adverse effect on every one and thing. they will become there one person not the one you once admire and loved. there is only one perfect being its god which we are not. medical scientist can not take a whole strain of dna it will have gaps in it. they fill these gaps with virus. who you want to live with someone that has a virus the could become ill all the time or pass it on.

amin
January 26, 2009 - 00:51
Subject:

is it possible to make a new type of human with special abilities by cloning?

garret
January 13, 2009 - 21:13
Subject: cloning

The person will essentially be a whole new being and may not even act like the cloned person they will only look alike

Deward
December 08, 2008 - 08:46
Subject: cloning

Class project

Reply to Deward
Cory
January 13, 2009 - 09:55
Subject: Re: cloning

The new person wouldn't be the same mentally as the person that lived previously. They would just simply be a physical copy of the dead person.

Reply to Deward
mrs robinson
February 25, 2009 - 03:45
Subject: Re: cloning

william this isn't the best site for your case study. there are better places than this many of these arguments are one sided

Grant
December 07, 2008 - 17:46
Subject: CLoning

If you clone a dead relative, they wouldn't have the same experiences they did, and that would/could change the very essence of that person.

ashley
December 05, 2008 - 14:02
Subject:

i really do think that human cloning should be apart of the world. i think that is a great idea of the usa. i think that dead people should be cloned cause then you can come back to life and be with the ones they love again. :]]

Brianna
December 04, 2008 - 13:12
Subject: cloneing dead tissue

I think it would be a good idea but I think people would come to relize it wouldn't be the same. Other wise I'm totally up on the idea. now cloneing for the perpose of just cell and tissue for desies and not keaping them alive is just kind of wrong. we should see how they turn out. nothing personal I think the research is great and so I'd have to say keep up the good work!

dan
November 07, 2008 - 07:53
Subject: cloning

was it hard to clone a mouse

Reply to dan
bob
February 25, 2009 - 03:43
Subject: Re: cloning

no chavs can do it in their sleep

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